Valérie Mongrain, Ph.D.

	Research Professor, Department of Psychiatry, Université de Montréal Director of the Molecular Sleep Physiology Lab 514-338-2222 ext. 3323 valerie.mongrain(at)umontreal.ca Education: Post-doctorate in Neurosciences (University of Lausanne) Post-doctorate in Psychiatry (McGill University) Ph.D. in Neurological Sciences (Université de Montréal) M.Sc. in Neurological Sciences (Université de Montréal) Research Interests: The molecular regulation of sleep and biological rhythms. Links between sleep homeostasis and synaptic plasticity. Involvement of synaptic adhesion proteins in regulating sleep. Pathophysiology of sleep disorders and associations between sleep disorders and psychiatric diseases. Methodologies: Electrophysiology (EEG and EMG), EEG spectral analysis, telemetry, molecular biology (e.g., quantification of messenger RNA and protein expression, and of protein-protein and protein-DNA interactions by immunoprecipitation).
Team in training:
	Janine El Helou, B.Sc. in Biological Sciences (Université de Montréal)   M.Sc. candidate in Biomedical sciences (Université de Montréal)   2011-ongoing   Subject title : Expression of synaptic adhesion proteins as a function of sleep   pressure
	Marlène Freyburger, M.Sc. in Neurosciences (University of Strasbourg)   Ph.D. candidate in Neurological Sciences (Université de Montréal)   2011-ongoing   Subject title : Role of several families of synaptic adhesion molecules in   sleep homeostasis and the circadian timing system
	Pierre-Olivier Gaudreault (Nadia Gosselin, co-director)   Undergraduate trainee   B.Sc. candidate in Psychologie (Université de Montréal)   Subject title: Traumatic brain injury, sleep and synaptic plasticity

 

 

Recent publications:

 

Hasan S, Dauvilliers Y, Mongrain V, Franken P, Tafti M. Age-related changes in sleep in inbred mice are genotype dependent. Neurobiol Aging 2012, 33(1), 195.e13-26.

 

Mongrain V, La Spada F, Curie T, Franken P. Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex. PLoS ONE 2011, 6(10), e26622.

 

Mongrain V, Carrier J, Paquet J, Bélanger-Nelson E, Dumont M. Morning and evening-type differences in slow waves during NREM sleep reveal both trait and state-dependent phenotypes. PLoS ONE 2011, 6(8), e22679.

 

Mongrain V, Hernandez SA, Pradervand S, Dorsaz S, Curie T, Hagiwara G, Gip P, Heller HC, Franken P. Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis. Sleep 2010, 33(9), 1147-57.

 

Mongrain V, Ruan X, Dardente H, Fortier EE, Cermakian N. Clock-dependent and independent transcriptional control of the two isoforms from the mouse Rorgamma gene. Genes Cells 2008, 13(12), 1197-210.

 

Touchette E, Mongrain V, Petit D, Tremblay RE, Montplaisir JY. Development of sleep-wake schedules during childhood and relationship with sleep duration. Arch Pediatr Adolesc Med 2008, 162(4):343-9.

Mongrain V, Noujaim J, Blais H, Dumont M. Daytime vigilance in chronotypes: Diurnal variations and effects of behavioral sleep fragmentation. Behav Brain Res 2008, 190, 105-11.

Mongrain V, Dumont M. Increased homeostatic response to behavioral sleep fragmentation in morning compared to evening types. Sleep 2007, 30, 773-80.

Goulet G, Mongrain V, Desrosiers C, Paquet J, Dumont M. Daily light exposure in morning-type and evening-type individuals. J Biol Rhythms 2007, 22, 151-8.

Mongrain V, Carrier J, Dumont M. Difference in sleep regulation between morning and evening circadian types as indexed by antero-posterior analyses of the sleep EEG. Eur J Neurosci 2006, 23, 497-504.