Simon Warby, Ph.D.

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Assistant Professor
Department of Psychiatry, Université de Montréal
Holder of the Chair Pfizer, Bristol-Myers Squibb, SmithKline Beecham, Eli Lilly in psychopharmacology at the Université de Montréal
514-338-2222
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Education:
Post-doctorate in Psychiatry (Stanford University)
Post-doctorate in Medical Genetics (University of British Columbia)
Ph.D. in Neuroscience (University of British Columbia)

Research Interests:
The genetic basis and modifiers of sleep disorders. The genetic and molecular regulation of normal brain activity during sleep. Pathophysiology and associations between sleep disorders and neurodegenerative/psychiatric diseases. Polysomnography (PSG) and electroencephalography (EEG) - based biomarkers of disease.

Methodologies:
Computational analysis of PSG and EEG signals, genetics and genome-wide association studies, bioinformatics. Molecular biology and molecular genetics including cloning. DNA/RNA/protein assessment & interactions, and in vitro assays.

Now recruiting Graduate Students and Postdoctoral Fellows

Chosen Publications:
Wendt SL, Welinder P, Sorensen HBD, Jennum P, Peppard PE, Perona P, Mignot E, and Warby SC. Inter-expert and intra-expert reliability in sleep spindle scoring. Clinical Neurophysiology 2015, 126(8):1548-56.

Christensen JAE, Nikolic M, Warby SC, Koch H, Zoetmulder M, Frandsen R, Moghadam KK, Sorensen HBD, Mignot E, Jennum PJ. Sleep spindle alterations in patients with Parkinson’s disease. Frontiers in Human Neuroscience 2015, 9:233.

Kay C, Collins JA, Skotte NH, Southwell AL, Warby SC, Caron NS, Doty CN, Ng B, Griguoli A, Ross C, Squitieri F, Hayden MR. Huntingtin haplotypes provide prioritized target panels for allele specific silencing in Huntington disease patients of European ancestry. Molecular Therapy 2015, 23(11): 1759-71.

Bečanović K, Neal SJ, Kay C, Nørremølle A, Collins JA, Arenillas D, Lilja T, Manoharan S, Doty C, Beck J, Lahiri N, Portales-Casamar E, Warby SC, Connolly C, De Souza RAG, REGISTRY Investigators of the European Huntington’s Disease Network, Tabrizi SJ, Hermanson O, Hayden MR, Langbehn DR, Wasserman WW, and Leavitt BR. A HTT Promoter SNP is a bidirectional genetic modifier of Huntington disease age of onset. Nature Neuroscience 2015, 18(6): 807-16.

Gottlieb DJ, Hek K, Chen T, Watson NF, Eiriksdottir G, Cornelis M, Warby SC, Bandinelli S, Byrne EM, Cherkas L, Evans DE, Grabe HJ, Lahti J, Li M, Lehtimäki T, Lumley T, Marciante KD, Pérusse L, Psaty BM, Robbins J, Tranah GJ, Vink JM, Wilk JB, Andrews JS, Bellis C, Biffar R, Bouchard C, Cade B, Curhan GC, Eriksson JG, Ewert RE, Ferrucci LF, Fülöp TF, Gehrman PR, Goodloe R, Harris TB, Heath AC, Hernandez D, Hofman A, Hottenga JJ, Hunter DJ, Jensen MK, Johnson AD, Kähönen MK, Kao LK, Kraft P, Larkin EK, Lauderdale DS, Luik AI, Medici MM, Montgomery GW, Palotie A, Patel SR, Pistis G, Porcu E, Quaye L, Raitakari O, Redline S, Rimm EB, Rotter JI, Smith AV, Spector T, Teumer A, Uitterlinden AG, Vohl MC,  Widen E, Willemsen G, Young TY, Zhang X, Liu Y, Blangero J, Boomsma DI, Gudnason V, Hu F, Mangino M, Martin NG, O’Connor GT, Stone KL, Tanaka T, Viikari J, Gharib SA, Punjabi NM, Räikkönen K, Völzke H, Mignot E, Tiemeier H. Novel loci associated with usual sleep duration: The CHARGE Consortium genomewide association study. Molecular Psychiatry 2015, 20(10): 1232-9.