Research

Mild cognitive impairment:

Assess the predictive value of quantitative electroencephalography (qEEG) and of brain imaging (Single-Photon Emission Computerized Tomography (SPECT)) measured during REM sleep compared to other markers in patients with mild cognitive impairment, such as qEEG and SPECT during wakefulness, specific neuropsychological tests and brain morphometry, in order to identify subjects who will convert to Alzheimer’s disease at a three-year follow-up.
Collaborators: Isabelle Rouleau, Jean-François Gagnon, Nadia Gosselin, Jean-Paul Soucy, Serge Gauthier, Marie-Jeanne Kergoat

Somnambulism:

Study the slow-wave sleep processes during normal sleep and after sleep deprivation in sleepwalkers and controls using quantitative EEG and brain imaging (single photon emission computed tomography (SPECT)), and use waking EEG recordings, vigilance tasks and SPECT imaging to investigate electrophysiological and neurobiological processes during normal wakefulness and following sleep deprivation in sleepwalkers and controls.
Collaborators: Antonio Zadra, Jean-Paul Soucy

REM behavior disorder:

Evaluate the evolution of the neurological (motor and sensory) and cognitive (memory, attention, language, visuospatial perception) functions, that of the brain electrical activity during wakefulness and during sleep and that of the brain imaging of patients diagnosed with REM sleep behavior disorder. The purpose of the study is to verify whether some of these tests can predict the short-term occurrence of a neurodegenerative disease and to study how these markers progress in preclinical stages.
Collaborators: Jean-François Gagnon, Ron Postuma, Jean-Paul Soucy

Longitudinal study of sleep in children and adolescents:

Study in a large cohort of children in Quebec the evolution of sleeping patterns from birth to adolescence, prevalence of and factors associated with dyssomnias and parasomnias, and the consequences of insufficient nighttime sleep duration in early childhood on various child development domains (cognitive performance, language, behavior of overweight and obesity hyperactive-impulsive, etc.).
Collaborators: Richard Tremblay, Michel Boivin, Frank Vitaro

Team

Lab Members:

	Dominique Petit, Ph.D. Research Coordinator Ph.D. in Neurological Sciences (Université de Montréal)
	Shady Rahayel, B.Sc. Ph.D. candidate in Neuropsychology R/I, Université du Québec à Montréal Co-direction with Dr Jean-François Gagnon Cerebral structural abnormalities in REM behavior disorder
	Pauline Brayet, B.Sc.  Ph.D. candidate in Neuropsychology R/I, Université du Québec à Montréal Co-direction with Dre Isabelle Rouleau REM sleep: a marker of amnestic mild cognitive impairment
	Daphné Génier Marchand, B.Sc. Ph.D. candidate in Neuropsychology R/I, Université du Québec à Montréal Co-direction with Dr Jean-François Gagnon, Longitudinal follow up of cognitive profile in the REM behavior disorder

Previous Lab Members:

	Jessica Rodrigues-Brazète, Ph.D. Ph.D. in Psychology R/I, Université de Montréal Co-direction with Dr Jean-François Gagnon REM sleep behavior disorder: study of EEG markers predictive of neurodegenerative diseases
	Marc-Antoine Labelle, Ph.D. Ph.D. candidate in Psychology R/I, Université de Montréal Co-direction with Dr Antonio Zadra Sleepwalking pathophysiology
	Mélanie Vendette, Ph.D. Ph.D. in Neuropsychology R/I, Université de Montréal Co-direction with Dr Jean-François Gagnon REM sleep behavior disorder: SPECT studies

Publications

Rodrigues Brazète J, Gagnon JF, Postuma RB, Bertrand JA, Petit D, Montplaisir J. Electroencephalogram slowing predicts neurodegeneration in rapid eye movement sleep behavior disorder. Neurobiol Aging 2016, 37, 74-81.

Petit D, Pennestri MH, Paquet J, Desautels A, Zadra A, Vitaro F, Tremblay RE, Boivin M, Montplaisir J. Childhood Sleepwalking and Sleep Terrors: A Longitudinal Study of Prevalence and Familial Aggregation. JAMA Pediatr 2015, 169(7): 653-8.

Dang-Vu TT, Zadra A, Labelle MA, Petit D, Soucy JP, Montplaisir J. Sleep Deprivation Reveals Altered Brain Perfusion Patterns in Somnambulism. PLoS One 2015, 10(8), e0133474.

Montplaisir J, Petit D, Quinn MJ, Ouakki M, Deceuninck G, Desautels A, Mignot E, De Wals P. Risk of narcolepsy associated with inactivated adjuvanted (AS03) A/H1N1 (2009) pandemic influenza vaccine in Quebec. PLoS One 2014, 9(9): e108489.

Peever J, Luppi PH, Montplaisir J. Breakdown in REM sleep circuitry underlies REM sleep behavior disorder. Trends Neurosci 2014, 37(5): 279-88.

Zadra A, Desautels A, Petit D, Montplaisir J. Somnambulism: clinical aspects and pathophysiological hypotheses. Lancet Neurol 2013, 12(3): 285-94.

Postuma RB, Gagnon JF, Tuineaig M, Bertrand JA, Latreille V, Desjardins C, Montplaisir JY. Antidepressants and REM sleep behavior disorder: isolated side effect or neurodegenerative signal? Sleep 2013, 36(11), 1579-1585.

ostuma RB, Lang AE, Gagnon JF, Pelletier A, Montplaisir JY. How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Brain 2012, 135(Pt 6): 1860-70.

Tatone-Tokuda F, Dubois L, Ramsay T, Girard M, Touchette E, Petit D, Montplaisir JY. Sex differences in the association between sleep duration, diet and body mass index: a birth cohort study. J Sleep Res 2012, 21(4), 448-460.

Montplaisir J, Gagnon JF, Fantini ML, Postuma RB, Dauvilliers Y, Desautels A, Rompré S, Paquet J. Polysomnographic diagnosis of idiopathic REM sleep behavior disorder. Mov Disord 2010, 25(13), 2044-2051.

Postuma RB, Lanfranchi PA, Blais H, Gagnon JF, Montplaisir JY. Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder. Mov Disord 2010, 25(14), 2304-2310.

Postuma RB, Gagnon JF, Montplaisir J. Clinical prediction of Parkinson's disease: planning for the age of neuroprotection. J Neurol Neurosurg Psychiatry 2010, 81(9), 1008-1013.

Whittom S, Dumont M, Petit D, Desautels A, Adam B, Lavigne G, Montplaisir J. Effects of melatonin and bright light administration on motor and sensory symptoms of RLS. Sleep Med 2010, 11(4), 351-355.

Postuma RB, Gagnon JF, Rompré S, Montplaisir JY. Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease. Neurology 2010, 74(3), 239-244.

Touchette E, Côté SM, Petit D, Liu X, Boivin M, Falissard B, Tremblay RE, Montplaisir JY. Short nighttime sleep-duration and hyperactivity trajectories in early childhood. Pediatrics 2009, 124(5), e985-993.

Lanfranchi PA, Pennestri MH, Fradette L, Dumont M, Morin CM, Montplaisir J. Nighttime blood pressure in normotensive subjects with chronic insomnia: implications for cardiovascular risk. Sleep 2009, 32(6), 760-766,.

Nguyen BH, Pérusse D, Paquet J, Petit D, Boivin M, Tremblay RE, Montplaisir J. Sleep terrors in children: a prospective study of twins. Pediatrics 2008, 122(6), e1164-1167.

Zadra A, Pilon M, Montplaisir J. Polysomnographic diagnosis of sleepwalking: effects of sleep deprivation. Ann Neurol 2008, 63(4), 513-519.

Massicotte-Marquez J, Décary A, Gagnon JF, Vendette M, Mathieu A, Postuma RB, Carrier J, Montplaisir J. Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder. Neurology 2008, 70, 1250-1257.